Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress

PREP1 (PKNOX1) maps in the Down syndrome (DS) critical region of chromosome 21, is overexpressed in some DS tissues and might be involved in the DS phenotype. By using fibroblasts from DS patients and by overexpressing Prep1 in F9 teratocarcinoma and Prep1(i/i) MEF to single out the role of the prot...

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Detalles Bibliográficos
Autores principales: Micali, Nicola, Longobardi, Elena, Iotti, Giorgio, Ferrai, Carmelo, Castagnaro, Laura, Ricciardi, Mario, Blasi, Francesco, Crippa, Massimo P.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887940/
https://www.ncbi.nlm.nih.gov/pubmed/20110257
http://dx.doi.org/10.1093/nar/gkq019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887940/
https://www.ncbi.nlm.nih.gov/pubmed/20110257
http://dx.doi.org/10.1093/nar/gkq019

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