A malignant hyperthermia–inducing mutation in RYR1 (R163C): alterations in Ca(2+) entry, release, and retrograde signaling to the DHPR

Bidirectional signaling between the sarcolemmal L-type Ca(2+) channel (1,4-dihydropyridine receptor [DHPR]) and the sarcoplasmic reticulum (SR) Ca(2+) release channel (type 1 ryanodine receptor [RYR1]) of skeletal muscle is essential for excitation–contraction coupling (ECC) and is a well-understood...

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Detalles Bibliográficos
Autores principales: Estève, Eric, Eltit, José M., Bannister, Roger A., Liu, Kai, Pessah, Isaac N., Beam, Kurt G., Allen, Paul D., López, José R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888056/
https://www.ncbi.nlm.nih.gov/pubmed/20479110
http://dx.doi.org/10.1085/jgp.200910328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888056/
https://www.ncbi.nlm.nih.gov/pubmed/20479110
http://dx.doi.org/10.1085/jgp.200910328

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