Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts

INTRODUCTION: Extracellular matrix (ECM) turnover is controlled by the synthetic rate of matrix proteins, including type I collagen, and their enzymatic degradation by matrix metalloproteinases (MMPs). Fibrosis is characterized by an unbalanced accumulation of ECM leading to organ dysfunction as obs...

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Detalles Bibliográficos
Autores principales: Goffin, Laurence, Seguin-Estévez, Queralt, Alvarez, Montserrat, Reith, Walter, Chizzolini, Carlo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888229/
https://www.ncbi.nlm.nih.gov/pubmed/20429888
http://dx.doi.org/10.1186/ar2991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888229/
https://www.ncbi.nlm.nih.gov/pubmed/20429888
http://dx.doi.org/10.1186/ar2991

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