Helical assembly in the MyD88:IRAK4:IRAK2 complex in TLR/IL-1R signaling

MyD88, IRAK4 and IRAK2 are critical signaling mediators of the TLR/IL1-R superfamily. Here we report the crystal structure of the MyD88: IRAK4: IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MyD88, 4 IRAK4 and 4 IRAK2 DDs. Assembly of th...

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Detalles Bibliográficos
Autores principales: Lin, Su-Chang, Lo, Yu-Chih, Wu, Hao
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888693/
https://www.ncbi.nlm.nih.gov/pubmed/20485341
http://dx.doi.org/10.1038/nature09121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888693/
https://www.ncbi.nlm.nih.gov/pubmed/20485341
http://dx.doi.org/10.1038/nature09121

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