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Elastic network model of allosteric regulation in protein kinase PDK1
BACKGROUND: Structural switches upon binding of phosphorylated moieties underpin many signalling networks. The ligand activation is a form of allosteric modulation of the protein, where the binding site is remote from the structural change in the protein. Recently this structural switch has been ele...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888814/ https://www.ncbi.nlm.nih.gov/pubmed/20500829 http://dx.doi.org/10.1186/1472-6807-10-11 |