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Direct Dynamic Protein-Affinity Selection Mass-Spectrometry
A new methodology is described enabling the affinity screening of potential ligands towards the human estrogen receptor alpha ligand binding domain (ERα-LBD). In-solution incubation is performed of the analyte and the His-tagged ERα-LBD. The bound complex is immobilized on a nickel-loaded protein-af...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Vieweg Verlag
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889285/ https://www.ncbi.nlm.nih.gov/pubmed/20628447 http://dx.doi.org/10.1365/s10337-010-1586-x |