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Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes
OBJECTIVE: Depletion of body fat stores during uncontrolled, insulin-deficient diabetes (uDM) results in markedly reduced plasma leptin levels. This study investigated the role of leptin deficiency in the genesis of severe insulin resistance and related metabolic and neuroendocrine derangements indu...
Autores principales: | German, Jonathan P., Wisse, Brent E., Thaler, Joshua P., Oh-I, Shinsuke, Sarruf, David A., Ogimoto, Kayoko, Kaiyala, Karl J., Fischer, Jonathan D., Matsen, Miles E., Taborsky, Gerald J., Schwartz, Michael W., Morton, Gregory J. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889761/ https://www.ncbi.nlm.nih.gov/pubmed/20424233 http://dx.doi.org/10.2337/db09-1918 |
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