Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes

OBJECTIVE: Islet β-cells loose their ability to synthesize insulin under diabetic conditions, which is at least partially due to the decreased activity of insulin transcription factors such as MafA. Although an in vitro study showed that reactive oxygen species (ROS) decrease MafA expression, the un...

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Detalles Bibliográficos
Autores principales: Matsuoka, Taka-aki, Kaneto, Hideaki, Miyatsuka, Takeshi, Yamamoto, Tsunehiko, Yamamoto, Kaoru, Kato, Ken, Shimomura, Iichiro, Stein, Roland, Matsuhisa, Munehide
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889771/
https://www.ncbi.nlm.nih.gov/pubmed/20424231
http://dx.doi.org/10.2337/db08-0693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889771/
https://www.ncbi.nlm.nih.gov/pubmed/20424231
http://dx.doi.org/10.2337/db08-0693

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