Cargando…
Simultaneous Detection of Circulating Autoreactive CD8(+) T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers
OBJECTIVE: Type 1 diabetes results from selective T-cell–mediated destruction of the insulin-producing β-cells in the pancreas. In this process, islet epitope–specific CD8(+) T-cells play a pivotal role. Thus, monitoring of multiple islet–specific CD8(+) T-cells may prove to be valuable for measurin...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889772/ https://www.ncbi.nlm.nih.gov/pubmed/20357361 http://dx.doi.org/10.2337/db09-1486 |