Simultaneous Detection of Circulating Autoreactive CD8(+) T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers

OBJECTIVE: Type 1 diabetes results from selective T-cell–mediated destruction of the insulin-producing β-cells in the pancreas. In this process, islet epitope–specific CD8(+) T-cells play a pivotal role. Thus, monitoring of multiple islet–specific CD8(+) T-cells may prove to be valuable for measurin...

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Detalles Bibliográficos
Autores principales: Velthuis, Jurjen H., Unger, Wendy W., Abreu, Joana R.F., Duinkerken, Gaby, Franken, Kees, Peakman, Mark, Bakker, Arnold H., Reker-Hadrup, Sine, Keymeulen, Bart, Drijfhout, Jan Wouter, Schumacher, Ton N., Roep, Bart O.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889772/
https://www.ncbi.nlm.nih.gov/pubmed/20357361
http://dx.doi.org/10.2337/db09-1486

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