ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions

BACKGROUND: Spinal cord neurons of ALS patients demonstrate reduced cytochrome oxidase histochemical activity, and ALS spinal cord tissues have increased mitochondrial DNA (mtDNA) point mutations and depleted mtDNA levels. It is presently unknown whether mtDNA abnormalities are present in single hum...

Descripción completa

Detalles Bibliográficos
Autores principales: Keeney, Paula M, Bennett, James P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889994/
https://www.ncbi.nlm.nih.gov/pubmed/20504367
http://dx.doi.org/10.1186/1750-1326-5-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889994/
https://www.ncbi.nlm.nih.gov/pubmed/20504367
http://dx.doi.org/10.1186/1750-1326-5-21

Ejemplares similares