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ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions
BACKGROUND: Spinal cord neurons of ALS patients demonstrate reduced cytochrome oxidase histochemical activity, and ALS spinal cord tissues have increased mitochondrial DNA (mtDNA) point mutations and depleted mtDNA levels. It is presently unknown whether mtDNA abnormalities are present in single hum...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889994/ https://www.ncbi.nlm.nih.gov/pubmed/20504367 http://dx.doi.org/10.1186/1750-1326-5-21 |