The 11-β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy

OBJECTIVE: 11-β-hydroxysteroid dehydrogenase type 1 (11βHSD1) converts inactive cortisone into active cortisol, thereby amplifying intracellular glucocorticoid action. The efficacy and safety of the 11βHSD1 inhibitor INCB13739 were assessed when added to ongoing metformin monotherapy in patients wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Rosenstock, Julio, Banarer, Salomon, Fonseca, Vivian A., Inzucchi, Silvio E., Sun, William, Yao, Wenqing, Hollis, Gregory, Flores, Robert, Levy, Richard, Williams, William V., Seckl, Jonathan R., Huber, Reid
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890352/
https://www.ncbi.nlm.nih.gov/pubmed/20413513
http://dx.doi.org/10.2337/dc09-2315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890352/
https://www.ncbi.nlm.nih.gov/pubmed/20413513
http://dx.doi.org/10.2337/dc09-2315

Ejemplares similares