Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation

BACKGROUND: Myogenesis in C2C12 cells requires the activation of the PI3K/mTOR signaling pathways. Since mTOR signaling can feedback through S6K1 to inhibit the activation of PI3K, the aim of this work was to assess whether feedback from S6K1 played a role in myogenesis and determine whether siRNA m...

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Detalles Bibliográficos
Autores principales: Hamilton, D Lee, Philp, Andrew, MacKenzie, Matthew G, Baar, Keith
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890513/
https://www.ncbi.nlm.nih.gov/pubmed/20507574
http://dx.doi.org/10.1186/1471-2121-11-37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890513/
https://www.ncbi.nlm.nih.gov/pubmed/20507574
http://dx.doi.org/10.1186/1471-2121-11-37

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