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Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation

BACKGROUND: Myogenesis in C2C12 cells requires the activation of the PI3K/mTOR signaling pathways. Since mTOR signaling can feedback through S6K1 to inhibit the activation of PI3K, the aim of this work was to assess whether feedback from S6K1 played a role in myogenesis and determine whether siRNA m...

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Detalles Bibliográficos
Autores principales:	Hamilton, D Lee, Philp, Andrew, MacKenzie, Matthew G, Baar, Keith
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890513/ https://www.ncbi.nlm.nih.gov/pubmed/20507574 http://dx.doi.org/10.1186/1471-2121-11-37

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