Three-dimensional structure of β-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W

BACKGROUND: We examined the effects of the R325W mutation on the three-dimensional (3D) structure of the β-cell-specific Zn(2+ )(zinc) transporter ZnT-8. METHODS: A model of the C-terminal domain of the human ZnT-8 protein was generated by homology modeling based on the known crystal structure of th...

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Detalles Bibliográficos
Autor principal: Weijers, Rob NM
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890542/
https://www.ncbi.nlm.nih.gov/pubmed/20525392
http://dx.doi.org/10.1186/1758-5996-2-33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890542/
https://www.ncbi.nlm.nih.gov/pubmed/20525392
http://dx.doi.org/10.1186/1758-5996-2-33

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