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Three-dimensional structure of β-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W
BACKGROUND: We examined the effects of the R325W mutation on the three-dimensional (3D) structure of the β-cell-specific Zn(2+ )(zinc) transporter ZnT-8. METHODS: A model of the C-terminal domain of the human ZnT-8 protein was generated by homology modeling based on the known crystal structure of th...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890542/ https://www.ncbi.nlm.nih.gov/pubmed/20525392 http://dx.doi.org/10.1186/1758-5996-2-33 |