Novel approach of high cell density recombinant bioprocess development: Optimisation and scale-up from microlitre to pilot scales while maintaining the fed-batch cultivation mode of E. coli cultures

BACKGROUND: Bioprocess development of recombinant proteins is time consuming and laborious as many factors influence the accumulation of the product in the soluble and active form. Currently, in most cases the developmental line is characterised by a screening stage which is performed under batch co...

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Detalles Bibliográficos
Autores principales: Šiurkus, Juozas, Panula-Perälä, Johanna, Horn, Uwe, Kraft, Mario, Rimšeliene, Renata, Neubauer, Peter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890543/
https://www.ncbi.nlm.nih.gov/pubmed/20487563
http://dx.doi.org/10.1186/1475-2859-9-35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890543/
https://www.ncbi.nlm.nih.gov/pubmed/20487563
http://dx.doi.org/10.1186/1475-2859-9-35

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