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Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology
Mutations in the presenilin-1 (PS1) gene are independent causes of familial Alzheimer's disease (AD). AD patients have dysregulated immunity, and PS1 mutant mice exhibit abnormal systemic immune responses. To test whether immune function abnormality caused by a mutant human PS1 gene (mhPS1) cou...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891003/ https://www.ncbi.nlm.nih.gov/pubmed/19900216 http://dx.doi.org/10.1111/j.1582-4934.2009.00962.x |