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Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology

Mutations in the presenilin-1 (PS1) gene are independent causes of familial Alzheimer's disease (AD). AD patients have dysregulated immunity, and PS1 mutant mice exhibit abnormal systemic immune responses. To test whether immune function abnormality caused by a mutant human PS1 gene (mhPS1) cou...

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Detalles Bibliográficos
Autores principales:	Zhu, Yuyan, Obregon, Demian, Hou, Huayan, Giunta, Brian, Ehrhart, Jared, Fernandez, Frank, Mori, Takashi, Nikolic, William, Zhao, Yangbing, Morgan, Dave, Town, Terrence, Tan, Jun
Formato:	Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891003/ https://www.ncbi.nlm.nih.gov/pubmed/19900216 http://dx.doi.org/10.1111/j.1582-4934.2009.00962.x

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