Roles of CUP-5, the Caenorhabditis elegans orthologue of human TRPML1, in lysosome and gut granule biogenesis

BACKGROUND: CUP-5 is a Transient Receptor Potential protein in C. elegans that is the orthologue of mammalian TRPML1. Loss of TRPML1 results in the lysosomal storage disorder Mucolipidosis type IV. Loss of CUP-5 results in embryonic lethality and the accumulation of enlarged yolk granules in develop...

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Detalles Bibliográficos
Autores principales: Campbell, Erin M, Fares, Hanna
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891664/
https://www.ncbi.nlm.nih.gov/pubmed/20540742
http://dx.doi.org/10.1186/1471-2121-11-40

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891664/
https://www.ncbi.nlm.nih.gov/pubmed/20540742
http://dx.doi.org/10.1186/1471-2121-11-40

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