Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

The transcription factor Nrf2 regulates expression of multiple cellular defence proteins through the antioxidant response element (ARE). Nrf2-deficient mice (Nrf2(−)(/)(−)) are highly susceptible to xenobiotic-mediated toxicity, but the precise molecular basis of enhanced toxicity is unknown. Oligon...

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Detalles Bibliográficos
Autores principales: Kitteringham, Neil R., Abdullah, Azman, Walsh, Joanne, Randle, Laura, Jenkins, Rosalind E., Sison, Rowena, Goldring, Christopher E.P., Powell, Helen, Sanderson, Christopher, Williams, Samantha, Higgins, Larry, Yamamoto, Masayuki, Hayes, John, Park, B. Kevin
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891861/
https://www.ncbi.nlm.nih.gov/pubmed/20399915
http://dx.doi.org/10.1016/j.jprot.2010.03.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891861/
https://www.ncbi.nlm.nih.gov/pubmed/20399915
http://dx.doi.org/10.1016/j.jprot.2010.03.018

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