DNA Damage Response and Tumorigenesis in Mcm2 Deficient Mice

Mini-chromosome maintenance proteins (Mcm’s) are components of the DNA replication licensing complex. In vivo, reduced expression or activity of Mcm proteins has been shown to result in highly penetrant early onset cancers (Shima et al., 2007; Pruitt et al., 2007 and stem cell deficiencies (Pruitt e...

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Detalles Bibliográficos
Autores principales: Kunnev, Dimiter, Rusiniak, Michael E., Kudla, Angela, Freeland, Amy, Cady, Gillian K., Pruitt, Steven C.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892019/
https://www.ncbi.nlm.nih.gov/pubmed/20440269
http://dx.doi.org/10.1038/onc.2010.125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892019/
https://www.ncbi.nlm.nih.gov/pubmed/20440269
http://dx.doi.org/10.1038/onc.2010.125

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