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5-HT(1A) receptor blockade reverses GABA(A) receptor α(3) subunit-mediated anxiolytic effects on stress-induced hyperthermia

RATIONALE: Stress-related disorders are associated with dysfunction of both serotonergic and GABAergic pathways, and clinically effective anxiolytics act via both neurotransmitter systems. As there is evidence that the GABA(A) and the serotonin receptor system interact, a serotonergic component in t...

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Detalles Bibliográficos
Autores principales: Vinkers, Christiaan H., van Oorschot, Ruud, Korte, S. Mechiel, Olivier, Berend, Groenink, Lucianne
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892061/
https://www.ncbi.nlm.nih.gov/pubmed/20535452
http://dx.doi.org/10.1007/s00213-010-1895-7