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Network properties of human disease genes with pleiotropic effects

BACKGROUND: The ability of a gene to cause a disease is known to be associated with the topological position of its protein product in the molecular interaction network. Pleiotropy, in human genetic diseases, refers to the ability of different mutations within the same gene to cause different pathol...

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Detalles Bibliográficos
Autores principales: Chavali, Sreenivas, Barrenas, Fredrik, Kanduri, Kartiek, Benson, Mikael
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892460/
https://www.ncbi.nlm.nih.gov/pubmed/20525321
http://dx.doi.org/10.1186/1752-0509-4-78