Environmental Exposure of the Mouse Germ Line: DNA Adducts in Spermatozoa and Formation of De Novo Mutations during Spermatogenesis

BACKGROUND: Spermatozoal DNA damage is associated with poor sperm quality, disturbed embryonic development and early embryonic loss, and some genetic diseases originate from paternal de novo mutations. We previously reported poor repair of bulky DNA-lesions in rodent testicular cells. METHODOLOGY/PR...

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Detalles Bibliográficos
Autores principales: Olsen, Ann-Karin, Andreassen, Åshild, Singh, Rajinder, Wiger, Richard, Duale, Nur, Farmer, Peter B., Brunborg, Gunnar
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893163/
https://www.ncbi.nlm.nih.gov/pubmed/20596530
http://dx.doi.org/10.1371/journal.pone.0011349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893163/
https://www.ncbi.nlm.nih.gov/pubmed/20596530
http://dx.doi.org/10.1371/journal.pone.0011349

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