Investigation of clinical interaction between omeprazole and tacrolimus in CYP3A5 non-expressors, renal transplant recipients

BACKGROUND: As proton pump inhibitors share CYP3A4 enzyme with tacrolimus for their hepatic elimination, they potentially affect its pharmacokinetics, most prominently in patients with CYP2C19 or CYP3A5 gene mutations. Our aim was to investigate the impact of omeprazole on tacrolimus pharmacokinetic...

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Detalles Bibliográficos
Autores principales: Katsakiori, Paraskevi F, Papapetrou, Eirini P, Goumenos, Dimitrios S, Nikiforidis, George C, Flordellis, Christodoulos S
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893758/
https://www.ncbi.nlm.nih.gov/pubmed/20596503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893758/
https://www.ncbi.nlm.nih.gov/pubmed/20596503

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