A Gαi–GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate

Cells respond to growth factors by either migrating or proliferating, but not both at the same time, a phenomenon termed migration-proliferation dichotomy. The underlying mechanism of this phenomenon has remained unknown. We demonstrate here that Gα(i) protein and GIV, its nonreceptor guanine nucleo...

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Detalles Bibliográficos
Autores principales: Ghosh, Pradipta, Beas, Anthony O., Bornheimer, Scott J., Garcia-Marcos, Mikel, Forry, Erin P., Johannson, Carola, Ear, Jason, Jung, Barbara H., Cabrera, Betty, Carethers, John M., Farquhar, Marilyn G.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893996/
https://www.ncbi.nlm.nih.gov/pubmed/20462955
http://dx.doi.org/10.1091/mbc.E10-01-0028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893996/
https://www.ncbi.nlm.nih.gov/pubmed/20462955
http://dx.doi.org/10.1091/mbc.E10-01-0028

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