Unregulated ARF6 Activation in Epithelial Cysts Generates Hyperactive Signaling Endosomes and Disrupts Morphogenesis

Tumor development in glandular tissues is associated with structural alterations in the hollow ducts and spherical structures that comprise such tissues. We describe a signaling axis involving sustained activation of the GTP-binding protein, ARF6, that provokes dramatic changes in the organization o...

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Detalles Bibliográficos
Autores principales: Tushir, Jogender S., Clancy, James, Warren, Andrew, Wrobel, Carolyn, Brugge, Joan S., D'Souza-Schorey, Crislyn
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893997/
https://www.ncbi.nlm.nih.gov/pubmed/20462959
http://dx.doi.org/10.1091/mbc.E09-09-0824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893997/
https://www.ncbi.nlm.nih.gov/pubmed/20462959
http://dx.doi.org/10.1091/mbc.E09-09-0824

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