Cyclosporin A Treatment of Leishmania donovani Reveals Stage-Specific Functions of Cyclophilins in Parasite Proliferation and Viability

BACKGROUND: Cyclosporin A (CsA) has important anti-microbial activity against parasites of the genus Leishmania, suggesting CsA-binding cyclophilins (CyPs) as potential drug targets. However, no information is available on the genetic diversity of this important protein family, and the mechanisms un...

Descripción completa

Detalles Bibliográficos
Autores principales: Yau, Wai-Lok, Blisnick, Thierry, Taly, Jean-François, Helmer-Citterich, Manuela, Schiene-Fischer, Cordelia, Leclercq, Olivier, Li, Jing, Schmidt-Arras, Dirk, Morales, Miguel A., Notredame, Cedric, Romo, Daniel, Bastin, Philippe, Späth, Gerald F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894131/
https://www.ncbi.nlm.nih.gov/pubmed/20614016
http://dx.doi.org/10.1371/journal.pntd.0000729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894131/
https://www.ncbi.nlm.nih.gov/pubmed/20614016
http://dx.doi.org/10.1371/journal.pntd.0000729

Ejemplares similares