Cyclosporin A Treatment of Leishmania donovani Reveals Stage-Specific Functions of Cyclophilins in Parasite Proliferation and Viability

BACKGROUND: Cyclosporin A (CsA) has important anti-microbial activity against parasites of the genus Leishmania, suggesting CsA-binding cyclophilins (CyPs) as potential drug targets. However, no information is available on the genetic diversity of this important protein family, and the mechanisms un...

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Detalles Bibliográficos
Autores principales: Yau, Wai-Lok, Blisnick, Thierry, Taly, Jean-François, Helmer-Citterich, Manuela, Schiene-Fischer, Cordelia, Leclercq, Olivier, Li, Jing, Schmidt-Arras, Dirk, Morales, Miguel A., Notredame, Cedric, Romo, Daniel, Bastin, Philippe, Späth, Gerald F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894131/
https://www.ncbi.nlm.nih.gov/pubmed/20614016
http://dx.doi.org/10.1371/journal.pntd.0000729

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