DNA polymerases ν and θ are required for efficient immunoglobulin V gene diversification in chicken

The chicken DT40 B lymphocyte line diversifies its immunoglobulin (Ig) V genes through translesion DNA synthesis–dependent point mutations (Ig hypermutation) and homologous recombination (HR)–dependent Ig gene conversion. The error-prone biochemical characteristic of the A family DNA polymerases Pol...

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Detalles Bibliográficos
Autores principales: Kohzaki, Masaoki, Nishihara, Kana, Hirota, Kouji, Sonoda, Eiichiro, Yoshimura, Michio, Ekino, Shigeo, Butler, John E., Watanabe, Masami, Halazonetis, Thanos D., Takeda, Shunichi
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894443/
https://www.ncbi.nlm.nih.gov/pubmed/20584917
http://dx.doi.org/10.1083/jcb.200912012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894443/
https://www.ncbi.nlm.nih.gov/pubmed/20584917
http://dx.doi.org/10.1083/jcb.200912012

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