Cargando…
A cation counterflux supports lysosomal acidification
The profound luminal acidification essential for the degradative function of lysosomes requires a counter-ion flux to dissipate an opposing voltage that would prohibit proton accumulation. It has generally been assumed that a parallel anion influx is the main or only counter-ion transport that enabl...
Autores principales: | Steinberg, Benjamin E., Huynh, Kassidy K., Brodovitch, Alexandre, Jabs, Sabrina, Stauber, Tobias, Jentsch, Thomas J., Grinstein, Sergio |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894458/ https://www.ncbi.nlm.nih.gov/pubmed/20566682 http://dx.doi.org/10.1083/jcb.200911083 |
Ejemplares similares
-
Optogenetic Acidification of Synaptic Vesicles and Lysosomes
por: Rost, Benjamin R., et al.
Publicado: (2015) -
Lysosomal pH and analysis of the counter ion pathways that support acidification
por: DiCiccio, Jessica E., et al.
Publicado: (2011) -
Extracellular Acidification Induces Lysosomal Dysregulation
por: Ordway, Bryce, et al.
Publicado: (2021) -
Aberrant Phase Separation of FUS Leads to Lysosome Sequestering and Acidification
por: Trnka, Franziska, et al.
Publicado: (2021) -
Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity
por: Folts, Christopher J., et al.
Publicado: (2016)