Expression Levels of a Kinesin-13 Microtubule Depolymerase Modulates the Effectiveness of Anti-Microtubule Agents

BACKGROUND: Chemotheraputic drugs often target the microtubule cytoskeleton as a means to disrupt cancer cell mitosis and proliferation. Anti-microtubule drugs inhibit microtubule dynamics, thereby triggering apoptosis when dividing cells activate the mitotic checkpoint. Microtubule dynamics are reg...

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Detalles Bibliográficos
Autores principales: Schimizzi, Gregory V., Currie, Joshua D., Rogers, Stephen L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894863/
https://www.ncbi.nlm.nih.gov/pubmed/20614032
http://dx.doi.org/10.1371/journal.pone.0011381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894863/
https://www.ncbi.nlm.nih.gov/pubmed/20614032
http://dx.doi.org/10.1371/journal.pone.0011381

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