Connecting Mutations of the RNA Polymerase II C-Terminal Domain to Complex Phenotypic Changes Using Combined Gene Expression and Network Analyses

The C-terminal domain (CTD) of the largest subunit in DNA-dependent RNA polymerase II (RNAP II) is essential for mRNA synthesis and processing, through coordination of an astounding array of protein-protein interactions. Not surprisingly, CTD mutations can have complex, pleiotropic impacts on phenot...

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Detalles Bibliográficos
Autores principales: Rogers, Carlyle, Guo, Zhenhua, Stiller, John W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894937/
https://www.ncbi.nlm.nih.gov/pubmed/20613981
http://dx.doi.org/10.1371/journal.pone.0011386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894937/
https://www.ncbi.nlm.nih.gov/pubmed/20613981
http://dx.doi.org/10.1371/journal.pone.0011386

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