Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors

Intestinal cells are constantly produced from a stem cell reservoir that gives rise to proliferating transient amplifying cells, which subsequently differentiate into one of the four principal cell types. Signalling pathways, including the Notch signalling pathway, coordinate these differentiation p...

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Detalles Bibliográficos
Autores principales: van Es, Johan H., de Geest, Natalie, van de Born, Maaike, Clevers, Hans, Hassan, Bassem A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895507/
https://www.ncbi.nlm.nih.gov/pubmed/20975679
http://dx.doi.org/10.1038/ncomms1017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895507/
https://www.ncbi.nlm.nih.gov/pubmed/20975679
http://dx.doi.org/10.1038/ncomms1017

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