Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations

BACKGROUND: Signal transduction processes mediated by phosphatidyl inositol phosphates affect a broad range of cellular processes such as cell cycle progression, migration and cell survival. The protein kinase AKT is one of the major effectors in this signaling network. Chronic AKT activation contri...

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Detalles Bibliográficos
Autores principales: Krech, Till, Thiede, Margarethe, Hilgenberg, Ellen, Schäfer, Reinhold, Jürchott, Karsten
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895615/
https://www.ncbi.nlm.nih.gov/pubmed/20546605
http://dx.doi.org/10.1186/1471-2407-10-287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895615/
https://www.ncbi.nlm.nih.gov/pubmed/20546605
http://dx.doi.org/10.1186/1471-2407-10-287

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