Loss of AMP-activated protein kinase α2 subunit in mouse β-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic β-cell function remains unclear. In the present stusy, we therefore investigated whether AMPK plays a critical function in β-cell glucose sensing and is required...

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Detalles Bibliográficos
Autores principales: Beall, Craig, Piipari, Kaisa, Al-Qassab, Hind, Smith, Mark A., Parker, Nadeene, Carling, David, Viollet, Benoit, Withers, Dominic J., Ashford, Michael L. J.
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895783/
https://www.ncbi.nlm.nih.gov/pubmed/20465544
http://dx.doi.org/10.1042/BJ20100231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895783/
https://www.ncbi.nlm.nih.gov/pubmed/20465544
http://dx.doi.org/10.1042/BJ20100231

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