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Loss of AMP-activated protein kinase α2 subunit in mouse β-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic β-cell function remains unclear. In the present stusy, we therefore investigated whether AMPK plays a critical function in β-cell glucose sensing and is required...

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Detalles Bibliográficos
Autores principales:	Beall, Craig, Piipari, Kaisa, Al-Qassab, Hind, Smith, Mark A., Parker, Nadeene, Carling, David, Viollet, Benoit, Withers, Dominic J., Ashford, Michael L. J.
Formato:	Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895783/ https://www.ncbi.nlm.nih.gov/pubmed/20465544 http://dx.doi.org/10.1042/BJ20100231

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