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PIP(2)-Binding Site in Kir Channels: Definition by Multiscale Biomolecular Simulations

[Image: see text] Phosphatidylinositol bisphosphate (PIP(2)) is an activator of mammalian inwardly rectifying potassium (Kir) channels. Multiscale simulations, via a sequential combination of coarse-grained and atomistic molecular dynamics, enabled exploration of the interactions of PIP(2) molecules...

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Detalles Bibliográficos
Autores principales:	Stansfeld, Phillip J., Hopkinson, Richard, Ashcroft, Frances M., Sansom, Mark S. P.
Formato:	Texto
Lenguaje:	English
Publicado:	American Chemical Society 2009
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895862/ https://www.ncbi.nlm.nih.gov/pubmed/19839652 http://dx.doi.org/10.1021/bi9013193

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