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Cloning large natural product gene clusters from the environment: Piecing environmental DNA gene clusters back together with TAR
A single gram of soil can contain thousands of unique bacterial species, of which only a small fraction is regularly cultured in the laboratory. Although the fermentation of cultured microorganisms has provided access to numerous bioactive secondary metabolites, with these same methods it is not pos...
Autores principales: | Kim, Jeffrey H, Feng, Zhiyang, Bauer, John D, Kallifidas, Dimitris, Calle, Paula Y, Brady, Sean F |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895911/ https://www.ncbi.nlm.nih.gov/pubmed/20577994 http://dx.doi.org/10.1002/bip.21450 |
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