Inhibition of FOXO3 Tumor Suppressor Function by βTrCP1 through Ubiquitin-Mediated Degradation in a Tumor Mouse Model

BACKGROUND: The ubiquitin-proteasome system is the primary proteolysis machine for controlling protein stability of the majority of regulatory proteins including those that are critical for cancer development. The forkhead box transcription factor FOXO3 plays a key role in regulating tumor suppressi...

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Detalles Bibliográficos
Autores principales: Tsai, Wen-Bin, Chung, Young Min, Zou, Yiyu, Park, See-Hyoung, Xu, Zhaohui, Nakayama, Keiko, Lin, Sue-Hwa, Hu, Mickey C-T.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896402/
https://www.ncbi.nlm.nih.gov/pubmed/20625400
http://dx.doi.org/10.1371/journal.pone.0011171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896402/
https://www.ncbi.nlm.nih.gov/pubmed/20625400
http://dx.doi.org/10.1371/journal.pone.0011171

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