Cargando…

The impact of intragenic CpG content on gene expression

The development of vaccine components or recombinant therapeutics critically depends on sustained expression of the corresponding transgene. This study aimed to determine the contribution of intragenic CpG content to expression efficiency in transiently and stably transfected mammalian cells. Based...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bauer, Asli Petra, Leikam, Doris, Krinner, Simone, Notka, Frank, Ludwig, Christine, Längst, Gernot, Wagner, Ralf
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896515/ https://www.ncbi.nlm.nih.gov/pubmed/20203083 http://dx.doi.org/10.1093/nar/gkq115

Ejemplares similares

CpG domains downstream of TSSs promote high levels of gene expression
por: Krinner, Simone, et al.
Publicado: (2014)

Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing
por: Amante, Samuele M, et al.
Publicado: (2020)

The homeodomain of Oct4 is a dimeric binder of methylated CpG elements
por: Tan, Daisylyn Senna, et al.
Publicado: (2023)

Cytosine methylation at CpCpG sites triggers accumulation of non-CpG methylation in gene bodies
por: Zabet, Nicolae Radu, et al.
Publicado: (2017)

No evidence of extensive non-CpG methylation in mtDNA
por: Guitton, Romain, et al.
Publicado: (2022)

Implications of CpG islands on chromosomal architectures and modes of global gene regulation
por: Beck, Samuel, et al.
Publicado: (2018)

DNA methylation in human epigenomes depends on local topology of CpG sites
por: Lövkvist, Cecilia, et al.
Publicado: (2016)

Human mitochondrial DNA is extensively methylated in a non-CpG context
por: Patil, Vibha, et al.
Publicado: (2019)

Suppression of intragenic transcription requires the MOT1 and NC2 regulators of TATA-binding protein
por: Koster, Maria J. E., et al.
Publicado: (2014)

Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved
por: Long, Hannah K., et al.
Publicado: (2016)

Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development
por: Ichiyanagi, Tomoko, et al.
Publicado: (2013)

MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters
por: Okuda, Hiroshi, et al.
Publicado: (2014)

Collaboration between CpG sites is needed for stable somatic inheritance of DNA methylation states
por: Haerter, Jan O., et al.
Publicado: (2014)

Effects of non-CpG site methylation on DNA thermal stability: a fluorescence study
por: Nardo, Luca, et al.
Publicado: (2015)

GC skew is a conserved property of unmethylated CpG island promoters across vertebrates
por: Hartono, Stella R., et al.
Publicado: (2015)

Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting
por: Patiño-Parrado, Iris, et al.
Publicado: (2017)

DNA strand asymmetry generated by CpG hemimethylation has opposing effects on CTCF binding
por: Thomas, Stacey L, et al.
Publicado: (2023)

Transcriptional activation of yeast genes disrupts intragenic nucleosome phasing
por: Cui, Feng, et al.
Publicado: (2012)

CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity
por: Evison, Benny J., et al.
Publicado: (2009)

A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands
por: Kong, Lingchun, et al.
Publicado: (2016)

Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters
por: Ni, Weiya, et al.
Publicado: (2020)

Single-molecule mitochondrial DNA sequencing shows no evidence of CpG methylation in human cells and tissues
por: Bicci, Iacopo, et al.
Publicado: (2021)

Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites
por: Kozlenkov, Alexey, et al.
Publicado: (2014)

Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites
por: Lee, Seung-Tae, et al.
Publicado: (2016)

Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences
por: Günther, Katharina, et al.
Publicado: (2013)

Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts
por: Zhang, Donghong, et al.
Publicado: (2017)

Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B mono-ubiquitination
por: Lee, Bum-Kyu, et al.
Publicado: (2017)

KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity
por: Turberfield, Anne H, et al.
Publicado: (2019)

Epigenetic regulation of intragenic transposable elements impacts gene transcription in Arabidopsis thaliana
por: Le, Tu N., et al.
Publicado: (2015)

Depositing centromere repeats induces heritable intragenic heterochromatin establishment and spreading in Arabidopsis
por: Liu, Zhang-Wei, et al.
Publicado: (2023)

Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island
por: Zhang, Yan, et al.
Publicado: (2012)

Novel roles of an intragenic G-quadruplex in controlling microRNA expression and cardiac function
por: Zhu, Min, et al.
Publicado: (2021)

Large-scale organization of ribosomal DNA chromatin is regulated by Tip5
por: Zillner, Karina, et al.
Publicado: (2013)

Comparative analysis using K-mer and K-flank patterns provides evidence for CpG island sequence evolution in mammalian genomes
por: Chae, Heejoon, et al.
Publicado: (2013)

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain
por: Weber, Lisa Marie, et al.
Publicado: (2022)

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance
por: Zizza, Pasquale, et al.
Publicado: (2016)

Nucleosomes protect DNA from DNA methylation in vivo and in vitro
por: Felle, Max, et al.
Publicado: (2011)

Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter
por: Kitsera, Nataliya, et al.
Publicado: (2017)

Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner
por: Zhang, Peng, et al.
Publicado: (2017)

Potential role of DNA methylation as a facilitator of target search processes for transcription factors through interplay with methyl-CpG-binding proteins
por: Kemme, Catherine A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nqms105c8eqg10spemfr7m7006