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Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei

Base J is a hypermodified DNA base localized primarily to telomeric regions of the genome of Trypanosoma brucei. We have previously characterized two thymidine-hydroxylases (TH), JBP1 and JBP2, which regulate J-biosynthesis. JBP2 is a chromatin re-modeling protein that induces de novo J-synthesis, a...

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Detalles Bibliográficos
Autores principales:	Cliffe, Laura J., Siegel, T.Nicolai, Marshall, Marion, Cross, George A. M., Sabatini, Robert
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896530/ https://www.ncbi.nlm.nih.gov/pubmed/20215442 http://dx.doi.org/10.1093/nar/gkq146

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