Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis

BACKGROUND: Matrix metalloproteinase (MMP) is involved in the upper airway remodeling process. We hypothesized that genetic variants of the MMP-9 gene are associated with cases of chronic rhinosinusitis with nasal polyposis. METHODS: We conducted a case-control study where 203 cases of chronic rhino...

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Autores principales: Wang, Ling-Feng, Chien, Chen-Yu, Tai, Chih-Feng, Kuo, Wen-Rei, Hsi, Edward, Juo, Suh-Hang Hank
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896930/
https://www.ncbi.nlm.nih.gov/pubmed/20529372
http://dx.doi.org/10.1186/1471-2350-11-85
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author Wang, Ling-Feng
Chien, Chen-Yu
Tai, Chih-Feng
Kuo, Wen-Rei
Hsi, Edward
Juo, Suh-Hang Hank
author_facet Wang, Ling-Feng
Chien, Chen-Yu
Tai, Chih-Feng
Kuo, Wen-Rei
Hsi, Edward
Juo, Suh-Hang Hank
author_sort Wang, Ling-Feng
collection PubMed
description BACKGROUND: Matrix metalloproteinase (MMP) is involved in the upper airway remodeling process. We hypothesized that genetic variants of the MMP-9 gene are associated with cases of chronic rhinosinusitis with nasal polyposis. METHODS: We conducted a case-control study where 203 cases of chronic rhinosinusitis with nasal polyposis and 730 controls were enrolled. Three tagging single nucleotide polymorphisms (SNPs) and one promoter functional SNP rs3918242 were selected. Hardy-Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated according to three inheritance modes. Haplotype analysis was also performed. Permutation was used to adjust for multiple testing. RESULTS: All four SNPs were in HWE. The T allele of promoter SNP rs3918242 was associated with chronic rhinosinusitis with nasal polyposis under the dominant (nominal p = 0.023, empirical p = 0.022, OR = 1.62) and additive models (nominal p= 0.012, empirical p = 0.011, OR = 1.60). The A allele of rs2274756 has a nominal p value of 0.034 under the dominant model and 0.020 under the additive model. Haplotype analysis including the four SNPs showed a global p value of 0.015 and the most significant haplotype had a p value of 0.0045. We did not see any SNP that was more significant in the recurrent cases. CONCLUSIONS: We concluded that MMP-9 gene polymorphisms may influence susceptibility to the development of chronic rhinosinusitis with nasal polyposis in Chinese population.
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spelling pubmed-28969302010-07-06 Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis Wang, Ling-Feng Chien, Chen-Yu Tai, Chih-Feng Kuo, Wen-Rei Hsi, Edward Juo, Suh-Hang Hank BMC Med Genet Research Article BACKGROUND: Matrix metalloproteinase (MMP) is involved in the upper airway remodeling process. We hypothesized that genetic variants of the MMP-9 gene are associated with cases of chronic rhinosinusitis with nasal polyposis. METHODS: We conducted a case-control study where 203 cases of chronic rhinosinusitis with nasal polyposis and 730 controls were enrolled. Three tagging single nucleotide polymorphisms (SNPs) and one promoter functional SNP rs3918242 were selected. Hardy-Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated according to three inheritance modes. Haplotype analysis was also performed. Permutation was used to adjust for multiple testing. RESULTS: All four SNPs were in HWE. The T allele of promoter SNP rs3918242 was associated with chronic rhinosinusitis with nasal polyposis under the dominant (nominal p = 0.023, empirical p = 0.022, OR = 1.62) and additive models (nominal p= 0.012, empirical p = 0.011, OR = 1.60). The A allele of rs2274756 has a nominal p value of 0.034 under the dominant model and 0.020 under the additive model. Haplotype analysis including the four SNPs showed a global p value of 0.015 and the most significant haplotype had a p value of 0.0045. We did not see any SNP that was more significant in the recurrent cases. CONCLUSIONS: We concluded that MMP-9 gene polymorphisms may influence susceptibility to the development of chronic rhinosinusitis with nasal polyposis in Chinese population. BioMed Central 2010-06-09 /pmc/articles/PMC2896930/ /pubmed/20529372 http://dx.doi.org/10.1186/1471-2350-11-85 Text en Copyright ©2010 Wang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Ling-Feng
Chien, Chen-Yu
Tai, Chih-Feng
Kuo, Wen-Rei
Hsi, Edward
Juo, Suh-Hang Hank
Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis
title Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis
title_full Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis
title_fullStr Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis
title_full_unstemmed Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis
title_short Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis
title_sort matrix metalloproteinase-9 gene polymorphisms in nasal polyposis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896930/
https://www.ncbi.nlm.nih.gov/pubmed/20529372
http://dx.doi.org/10.1186/1471-2350-11-85
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