Glucose sensing in the pancreatic beta cell: a computational systems analysis

BACKGROUND: Pancreatic beta-cells respond to rising blood glucose by increasing oxidative metabolism, leading to an increased ATP/ADP ratio in the cytoplasm. This leads to a closure of K(ATP )channels, depolarization of the plasma membrane, influx of calcium and the eventual secretion of insulin. Su...

Descripción completa

Detalles Bibliográficos
Autores principales: Fridlyand, Leonid E, Philipson, Louis H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896931/
https://www.ncbi.nlm.nih.gov/pubmed/20497556
http://dx.doi.org/10.1186/1742-4682-7-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896931/
https://www.ncbi.nlm.nih.gov/pubmed/20497556
http://dx.doi.org/10.1186/1742-4682-7-15

Ejemplares similares