Activation of GPR30 inhibits growth of prostate cancer cells via sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G2 cell-cycle arrest

G protein–coupled receptor 30 (GPR30) exhibits estrogen-binding affinity and mediates nongenomic signaling of estrogen to regulate cell growth. We here demonstrated for the first time, in contrast to the reported promoting action of GPR30 on the growth of breast and ovarian cancer cells, that activa...

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Detalles Bibliográficos
Autores principales: Chan, Queeny K.Y., Lam, Hung-Ming, Ng, Chi-Fai, Lee, Amy Y.Y., Chan, Eddie S.Y., Ng, Ho-Keung, Ho, Shuk-Mei, Lau, Kin-Mang
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897932/
https://www.ncbi.nlm.nih.gov/pubmed/20203690
http://dx.doi.org/10.1038/cdd.2010.20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897932/
https://www.ncbi.nlm.nih.gov/pubmed/20203690
http://dx.doi.org/10.1038/cdd.2010.20

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