Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes

[Image: see text] We show that natural products target proteins with a high number of protein−protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential...

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Autores principales: Dančík, Vlado, Seiler, Kathleen Petri, Young, Damian W., Schreiber, Stuart L., Clemons, Paul A.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898216/
https://www.ncbi.nlm.nih.gov/pubmed/20565092
http://dx.doi.org/10.1021/ja102798t
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author Dančík, Vlado
Seiler, Kathleen Petri
Young, Damian W.
Schreiber, Stuart L.
Clemons, Paul A.
author_facet Dančík, Vlado
Seiler, Kathleen Petri
Young, Damian W.
Schreiber, Stuart L.
Clemons, Paul A.
author_sort Dančík, Vlado
collection PubMed
description [Image: see text] We show that natural products target proteins with a high number of protein−protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential biological pathways, resulting in competitor death. This result also suggests that additional sources of small molecules will be required to discover drugs targeting the root causes of human disease in the future.
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spelling pubmed-28982162010-07-11 Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes Dančík, Vlado Seiler, Kathleen Petri Young, Damian W. Schreiber, Stuart L. Clemons, Paul A. J Am Chem Soc [Image: see text] We show that natural products target proteins with a high number of protein−protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential biological pathways, resulting in competitor death. This result also suggests that additional sources of small molecules will be required to discover drugs targeting the root causes of human disease in the future. American Chemical Society 2010-06-21 2010-07-14 /pmc/articles/PMC2898216/ /pubmed/20565092 http://dx.doi.org/10.1021/ja102798t Text en Copyright © 2010 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Dančík, Vlado
Seiler, Kathleen Petri
Young, Damian W.
Schreiber, Stuart L.
Clemons, Paul A.
Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes
title Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes
title_full Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes
title_fullStr Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes
title_full_unstemmed Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes
title_short Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes
title_sort distinct biological network properties between the targets of natural products and disease genes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898216/
https://www.ncbi.nlm.nih.gov/pubmed/20565092
http://dx.doi.org/10.1021/ja102798t
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