Cargando…

A Single Residue Switch for Mg(2+)-dependent Inhibition Characterizes Plant Class II Diterpene Cyclases from Primary and Secondary Metabolism

Class II diterpene cyclases mediate the acid-initiated cycloisomerization reaction that serves as the committed step in biosynthesis of the large class of labdane-related diterpenoid natural products, which includes the important gibberellin plant hormones. Intriguingly, these enzymes are differenti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mann, Francis M., Prisic, Sladjana, Davenport, Emily K., Determan, Mara K., Coates, Robert M., Peters, Reuben J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898348/ https://www.ncbi.nlm.nih.gov/pubmed/20430888 http://dx.doi.org/10.1074/jbc.M110.123307

Ejemplares similares

Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis: IMPLICATIONS FOR TUBERCULOSIS
por: Mann, Francis M., et al.
Publicado: (2009)

Insights into the catalysis of a lysine-tryptophan bond in bacterial peptides by a SPASM domain radical S-adenosylmethionine (SAM) peptide cyclase
por: Benjdia, Alhosna, et al.
Publicado: (2017)

Structure and Mechanism of the Diterpene Cyclase ent-Copalyl Diphosphate Synthase
por: Köksal, Mustafa, et al.
Publicado: (2011)

GUCY2D mutations in retinal guanylyl cyclase 1 provide biochemical reasons for dominant cone–rod dystrophy but not for stationary night blindness
por: Peshenko, Igor V., et al.
Publicado: (2021)

The Catalytic Architecture of Leukotriene C(4) Synthase with Two Arginine Residues
por: Saino, Hiromichi, et al.
Publicado: (2011)

Arginine 104 Is a Key Catalytic Residue in Leukotriene C(4) Synthase
por: Rinaldo-Matthis, Agnes, et al.
Publicado: (2010)

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
por: Pawelzik, Sven-Christian, et al.
Publicado: (2010)

Faster Protein Splicing with the Nostoc punctiforme DnaE Intein Using Non-native Extein Residues
por: Cheriyan, Manoj, et al.
Publicado: (2013)

The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis
por: Bailey, Samuel S., et al.
Publicado: (2018)

Roles of distal aspartate and arginine of B-class dye-decolorizing peroxidase in heterolytic hydrogen peroxide cleavage
por: Pfanzagl, Vera, et al.
Publicado: (2018)

trans-Acting Arginine Residues in the AAA+ Chaperone ClpB Allosterically Regulate the Activity through Inter- and Intradomain Communication
por: Zeymer, Cathleen, et al.
Publicado: (2014)

Scaffold stability and P14′ residue steric hindrance in the differential inhibition of FXIIa by Aedes aegypti trypsin inhibitor versus Infestin-4
por: Walvekar, Varsha Ashok, et al.
Publicado: (2022)

A unique cysteine-rich zinc finger domain present in a majority of class II ribonucleotide reductases mediates catalytic turnover
por: Loderer, Christoph, et al.
Publicado: (2017)

Novosphingobium aromaticivorans uses a Nu-class glutathione S-transferase as a glutathione lyase in breaking the β-aryl ether bond of lignin
por: Kontur, Wayne S., et al.
Publicado: (2018)

Origin of the Proton-transfer Step in the Cofactor-free (1H)-3-Hydroxy-4-oxoquinaldine 2,4-Dioxygenase: EFFECT OF THE BASICITY OF AN ACTIVE SITE HIS RESIDUE
por: Hernandez-Ortega, Aitor, et al.
Publicado: (2014)

Histidyl-tRNA Synthetase Urzymes: CLASS I AND II AMINOACYL tRNA SYNTHETASE URZYMES HAVE COMPARABLE CATALYTIC ACTIVITIES FOR COGNATE AMINO ACID ACTIVATION
por: Li, Li, et al.
Publicado: (2011)

Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering
por: Morrone, Dana, et al.
Publicado: (2009)

Nitro-fatty acids as activators of hSIRT6 deacetylase activity
por: Carreño, Mara, et al.
Publicado: (2021)

Ligand-bound Structures and Site-directed Mutagenesis Identify the Acceptor and Secondary Binding Sites of Streptomyces coelicolor Maltosyltransferase GlgE
por: Syson, Karl, et al.
Publicado: (2016)

Discovery of a microbial transglutaminase enabling highly site-specific labeling of proteins
por: Steffen, Wojtek, et al.
Publicado: (2017)

Structural and functional aspects of mannuronic acid–specific PL6 alginate lyase from the human gut microbe Bacteroides cellulosilyticus
por: Stender, Emil G. P., et al.
Publicado: (2019)

Analysis of ubiquitin recognition by the HECT ligase E6AP provides insight into its linkage specificity
por: Ries, Lena K., et al.
Publicado: (2019)

NrdH-Redoxin Protein Mediates High Enzyme Activity in Manganese-reconstituted Ribonucleotide Reductase from Bacillus anthracis
por: Crona, Mikael, et al.
Publicado: (2011)

Regulated Phosphorylation of a Major UDP-glucuronosyltransferase Isozyme by Tyrosine Kinases Dictates Endogenous Substrate Selection for Detoxification
por: Mitra, Partha S., et al.
Publicado: (2011)

A Conformational Sampling Model for Radical Catalysis in Pyridoxal Phosphate- and Cobalamin-dependent Enzymes
por: Menon, Binuraj R. K., et al.
Publicado: (2014)

A surface-exposed GH26 β-mannanase from Bacteroides ovatus: Structure, role, and phylogenetic analysis of BoMan26B
por: Bågenholm, Viktoria, et al.
Publicado: (2019)

Molecular and Thermodynamic Mechanisms of the Chloride-dependent Human Angiotensin-I-converting Enzyme (ACE)
por: Yates, Christopher J., et al.
Publicado: (2014)

Solution structure of the cytochrome P450 reductase–cytochrome c complex determined by neutron scattering
por: Freeman, Samuel L., et al.
Publicado: (2018)

(19)F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2
por: Ruben, Eliza A., et al.
Publicado: (2020)

Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases
por: Malcolm, Tess R., et al.
Publicado: (2021)

Human UTY(KDM6C) Is a Male-specific N(ϵ)-Methyl Lysyl Demethylase
por: Walport, Louise J., et al.
Publicado: (2014)

Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
por: Tchesnokov, Egor P., et al.
Publicado: (2020)

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases
por: Sengerová, Blanka, et al.
Publicado: (2012)

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites
por: Artz, Jennifer D., et al.
Publicado: (2011)

Galactomannan Catabolism Conferred by a Polysaccharide Utilization Locus of Bacteroides ovatus: ENZYME SYNERGY AND CRYSTAL STRUCTURE OF A β-MANNANASE
por: Bågenholm, Viktoria, et al.
Publicado: (2017)

Investigating the reaction and substrate preference of indole-3-acetaldehyde dehydrogenase from the plant pathogen Pseudomonas syringae PtoDC3000
por: Zhang, Kaleena, et al.
Publicado: (2020)

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase
por: Egger, Sigrid, et al.
Publicado: (2011)

Comparative Kinetic and Functional Characterization of the Motor Domains of Human Nonmuscle Myosin-2C Isoforms
por: Heissler, Sarah M., et al.
Publicado: (2011)

Regulation of Response Regulator Autophosphorylation through Interdomain Contacts
por: Barbieri, Christopher M., et al.
Publicado: (2010)

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY
por: Jin, Zhinan, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2m4b9siu04je9j3bjgm0ji8bng