High-quality crystals of human haematopoietic prostaglandin D synthase with novel inhibitors

Human haematopoietic prostaglandin D synthase (H-PGDS; EC 5.3.99.2) produces prostaglandin D(2), an allergic and inflammatory mediator, in mast cells and Th2 cells. H-PGDS has been crystallized with novel inhibitors with half-maximal inhibitory concentrations (IC(50)) in the low nanomolar range by t...

Descripción completa

Detalles Bibliográficos
Autores principales: Takahashi, Sachiko, Tsurumura, Toshiharu, Aritake, Kosuke, Furubayashi, Naoki, Sato, Masaru, Yamanaka, Mari, Hirota, Erika, Sano, Satoshi, Kobayashi, Tomoyuki, Tanaka, Tetsuo, Inaka, Koji, Tanaka, Hiroaki, Urade, Yoshihiro
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Crystallization Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898477/
https://www.ncbi.nlm.nih.gov/pubmed/20606289
http://dx.doi.org/10.1107/S1744309110020828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898477/
https://www.ncbi.nlm.nih.gov/pubmed/20606289
http://dx.doi.org/10.1107/S1744309110020828

Ejemplares similares